Dr.Lakshman Kumar Puli

Assistant Professor
M. Pharm., Ph.D.,PDF from USA and Sweden

Specialization :Pharmacology & Toxicology, Alzheimer’s Disease

E mail :Lakshman.puli@nmims.edu

Phone : 9985178048

Experience

9 years (Research abroad; PhD & Post doc) and 2 years (Teaching)

Dr. Lashman Puli worked alongside researchers, clinicians, and scientists from research institutions across Europe, USA and India. He got his PhD from University of Eastern Finland, Kuopio, Finland. He did his first Post doc at Weill Cornell Medical College, NewYork City, USA and his second post doc at Karolinska Institutet, Sweden. All along he focused on immunotherapies and animal models for Alzheimer’s Disease.

Research Profiles

https://scholar.google.com/citations?user=82EJ6zYAAAAJ&hl=en

https://www.scopus.com/authid/detail.uri?authorId=23668693700

Research Interests

Dr.Puli has always been fascinated by elusive brain immune cell nexus and antibody mediated immunomodulation for diagnosis and therapy of brain disorders. My main research focus has been on behavioral phenotyping, neuropathological characterization, transgenic animal models of Alzheimer’s Disease, immunotherapeutic approaches for brain disorders and novel biochemical assays. Dr.Puli’s goal is to harness scientific knowledge in pursuit of simple, economically viable solutions for societal problems relevant to therapeutic and diagnostic domains of CNS disorders.

Research areas

Alzheimer’s Disease

Neurodegenerative diseases

Antibodies for diagnosis and therapy of brain diseases

Immunomodulators

Behavioral phenotyping

Animal models

Environmental toxicants

Herbal products and Ayurveda

Research

Publications – Total number (International- 9 , National-1)

Presentations- Total number (International-6 , National-2 )

Conferences/Workshops/Seminars attended- 22

Awards

Leon Levy Neuroscience Fellowship 2013-2015

Alzheimer's association's travel fellowship for ICAD 2011

North Savo regional fund grant of Finnish cultural foundation in 2009.

Marie Curie EST (FP6) fellowship from BiND project, 2006-2009.

MHRD GATE Scholarship for Master’s degree in pharmacy for period 2003-2005.

Professional Memberships

Member of Association of Pharmaceutical Teachers of India.

Recent Publications

Herukka SK, Rummukainen J, Ihalainen J, von Und Zu Fraunberg M, Koivisto AM, Nerg O, Puli LK, Seppälä TT, Zetterberg H, Pyykkö OT, Helisalmi S, Tanila H, Alafuzoff I, Hiltunen M, Rinne J, Soininen H, Jääskeläinen JE, Leinonen V. Amyloid-β and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus. J Alzheimers Dis. 2015;46(1):261-9. (IF: 3.517) DOI: 10.3233/JAD-142862

Puli L, Tanila H, Relkin N. Intravenous immunoglobulins for Alzheimer's disease. Curr Alzheimer Res. 2014;11(7):626-36 (IF: 3.211) DOI: 10.2174/1567205011666140812113415

Puli L, Rolova T, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T. Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit. Neurobiol Dis. 2014 Apr; 64:16-29. (IF: 5.16) DOI: 10.1016/j.nbd.2013.12.003

Laiterä T, Sarajärvi T, Haapasalo A, Puli L, Kauppinen T, Mäkinen P, Rauramaa T, Tanila H, Jääskeläinen JE, Alafuzoff I, Soininen H, Leinonen V, Hiltunen M. Increased γ-secretase activity in idiopathic normal pressure hydrocephalus patients with β-amyloid pathology. PLoS One. 2014 Apr 3;9(4): e93717. (IF: 3.54) DOI:10.1371/journal.pone.0093717

Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V.Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus.PLoS One. 2014 Mar 17;9(3): e91974. (IF: 3.54) DOI: 10.1371/journal.pone.0091974.

Puli L, Pomeshchik Y, Olas K, Malm T, Koistinaho J, Tanila H. Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer's disease. J Neuroinflammation. 2012 May 29;9:105. (IF: 5.829) DOI: 10.1186/1742-2094-9-105

Toni T Seppälä, Ossi Nerg, Anne M Koivisto, Jaana Rummukainen, Lakshman Puli, Henrik Zetterberg, Okko T Pyykkö, Seppo Helisalmi, Irina Alafuzoff, MikkoHiltunen, Juha E Jääskeläinen, Jaakko Rinne, Hilkka Soininen, Ville Leinonen,and Sanna-Kaisa Herukka. Ventricular and lumbar CSF biomarkers for Alzheimer’s disease correlate with cortical brain biopsy findings. Neurology. 2012 May 15;78(20):1568-75. (IF: 8.689) DOI: 10.1212/WNL.0b013e3182563bd0

Carina Halleskog, Jan Mulder, Jenny Dahlström, Ken Mackie, Tibor Hortobágyi, Heikki Tanila, Lakshman Kumar Puli, Katrin Färber, Tibor Harkany,Gunnar Schulte. WNT signaling in activated microglia is pro-inflammatory. Glia. 2011Jan;59(1):119-31. (IF: 5.829) DOI: 10.1002/glia.21081

Magga J, Puli L, Pihlaja R, Kanninen K, Neulamaa S, Malm T, Härtig W, Grosche J, Goldsteins G, Tanila H, Koistinaho J, Koistinaho M.J. Human intravenous immunoglobulin provides protection against Aβ toxicity by multiple mechanisms in a mouse model of Alzheimer's disease. J Neuroinflammation. 2010 Dec 7; 7 : 90. (IF: 5.7) DOI: 10.1186/1742-2094-7-90.

Alley GM, Bailey JA, Chen D, Ray B, Puli LK, Tanila H, Banerjee PK, Lahiri DK. Memantine lowers amyloid-beta peptide levels in neuronal cultures and in APP/PS1 transgenic mice. J Neurosci Res 2009:88:143-154. (IF: 4.139)DOI: 10.1002/jnr.22172.